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Prothazine Brand names, Prothazine Analogs

Prothazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Prothazine Chemical_Formula


Prothazine RX_link

Prothazine fda sheet

Prothazine FDA

Prothazine msds (material safety sheet)

Prothazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Prothazine Molecular Weight

284.42 g/mol

Prothazine Melting Point


Prothazine H2O Solubility

Freely soluble

Prothazine State


Prothazine LogP


Prothazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Prothazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Prothazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Prothazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Prothazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Prothazine Patient Information

Prothazine Organisms Affected

Humans and other mammals