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Phenargan Brand names, Phenargan Analogs

Phenargan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Phenargan Chemical_Formula


Phenargan RX_link

Phenargan fda sheet

Phenargan FDA

Phenargan msds (material safety sheet)

Phenargan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Phenargan Molecular Weight

284.42 g/mol

Phenargan Melting Point


Phenargan H2O Solubility

Freely soluble

Phenargan State


Phenargan LogP


Phenargan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Phenargan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Phenargan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Phenargan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Phenargan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Phenargan Patient Information

Phenargan Organisms Affected

Humans and other mammals