Isopromethazine
Isopromethazine Brand names, Isopromethazine Analogs
- Allergan
- Aprobit
- Atosil
- Avomine
- Dimapp
- Diphergan
- Diprazine
- Diprozin
- Dorme
- Duplamin
- Fargan
- Fellozine
- Fenazil
- Fenergan
- Fenetazina
- Genphen
- Hiberna
- Histargan
- Iergigan
- Isophenergan
- Isopromethazine
- Lercigan
- Lergigan
- Lilly 1516
- Mymethazine Fortis
- Phargan
- Phenargan
- Phencen
- Phenergan
- Phenergan Fortis
- Phensedyl
- Pilpophen
- Pipolphen
- Proazaimine
- Proazamine
- Procit
- Promazinamide
- Prometasin
- Prometazin
- Prometh Fortis
- Prometh Plain
- Promethacon
- Promethaine
- Promethazin
- Promethazine Hcl
- Promethazine Plain
- Promethegan
- Promethiazine
- Promezathine
- Prorex
- Protazine
- Prothazin
- Prothazine
- Provigan
- Pyrethia
- Pyrethiazine
- Remsed
- Romergan
- Synalgos
- Tanidil
- Thiergan
- Valergine
- Vallergine
- Zipan-25
Isopromethazine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Isopromethazine Chemical_Formula
C17H20N2S
Isopromethazine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Isopromethazine fda sheet
Isopromethazine msds (material safety sheet)
Isopromethazine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Isopromethazine Molecular Weight
284.42 g/mol
Isopromethazine Melting Point
60oC
Isopromethazine H2O Solubility
Freely soluble
Isopromethazine State
Solid
Isopromethazine LogP
4.946
Isopromethazine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Isopromethazine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Isopromethazine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Isopromethazine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Isopromethazine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Isopromethazine Patient Information
Isopromethazine Organisms Affected
Humans and other mammals
