Isopromethazine en es it fr

Isopromethazine Brand names, Isopromethazine Analogs

Isopromethazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Isopromethazine Chemical_Formula


Isopromethazine RX_link

Isopromethazine fda sheet

Isopromethazine FDA

Isopromethazine msds (material safety sheet)

Isopromethazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Isopromethazine Molecular Weight

284.42 g/mol

Isopromethazine Melting Point


Isopromethazine H2O Solubility

Freely soluble

Isopromethazine State


Isopromethazine LogP


Isopromethazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Isopromethazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Isopromethazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Isopromethazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Isopromethazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Isopromethazine Patient Information

Isopromethazine Organisms Affected

Humans and other mammals