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Lergigan Brand names, Lergigan Analogs

Lergigan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Lergigan Chemical_Formula


Lergigan RX_link


Lergigan fda sheet

Lergigan FDA

Lergigan msds (material safety sheet)

Lergigan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Lergigan Molecular Weight

284.42 g/mol

Lergigan Melting Point


Lergigan H2O Solubility

Freely soluble

Lergigan State


Lergigan LogP


Lergigan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Lergigan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Lergigan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Lergigan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Lergigan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Lergigan Patient Information

Lergigan Organisms Affected

Humans and other mammals