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Promethazin Brand names, Promethazin Analogs

Promethazin Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethazin Chemical_Formula


Promethazin RX_link

Promethazin fda sheet

Promethazin FDA

Promethazin msds (material safety sheet)

Promethazin Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethazin Molecular Weight

284.42 g/mol

Promethazin Melting Point


Promethazin H2O Solubility

Freely soluble

Promethazin State


Promethazin LogP


Promethazin Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethazin Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethazin Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethazin Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethazin side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promethazin Patient Information

Promethazin Organisms Affected

Humans and other mammals