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Prometasin Brand names, Prometasin Analogs

Prometasin Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Prometasin Chemical_Formula


Prometasin RX_link

Prometasin fda sheet

Prometasin FDA

Prometasin msds (material safety sheet)

Prometasin Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Prometasin Molecular Weight

284.42 g/mol

Prometasin Melting Point


Prometasin H2O Solubility

Freely soluble

Prometasin State


Prometasin LogP


Prometasin Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Prometasin Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Prometasin Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Prometasin Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Prometasin side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Prometasin Patient Information

Prometasin Organisms Affected

Humans and other mammals