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Pipolphen Brand names, Pipolphen Analogs

Pipolphen Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Pipolphen Chemical_Formula


Pipolphen RX_link


Pipolphen fda sheet

Pipolphen FDA

Pipolphen msds (material safety sheet)

Pipolphen Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Pipolphen Molecular Weight

284.42 g/mol

Pipolphen Melting Point


Pipolphen H2O Solubility

Freely soluble

Pipolphen State


Pipolphen LogP


Pipolphen Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Pipolphen Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Pipolphen Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Pipolphen Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Pipolphen side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Pipolphen Patient Information

Pipolphen Organisms Affected

Humans and other mammals