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Promethegan Brand names, Promethegan Analogs

Promethegan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethegan Chemical_Formula


Promethegan RX_link

Promethegan fda sheet

Promethegan FDA

Promethegan msds (material safety sheet)

Promethegan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethegan Molecular Weight

284.42 g/mol

Promethegan Melting Point


Promethegan H2O Solubility

Freely soluble

Promethegan State


Promethegan LogP


Promethegan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethegan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethegan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethegan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethegan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promethegan Patient Information

Promethegan Organisms Affected

Humans and other mammals