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Promethacon Brand names, Promethacon Analogs

Promethacon Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethacon Chemical_Formula


Promethacon RX_link

Promethacon fda sheet

Promethacon FDA

Promethacon msds (material safety sheet)

Promethacon Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethacon Molecular Weight

284.42 g/mol

Promethacon Melting Point


Promethacon H2O Solubility

Freely soluble

Promethacon State


Promethacon LogP


Promethacon Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethacon Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethacon Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethacon Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethacon side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promethacon Patient Information

Promethacon Organisms Affected

Humans and other mammals