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Promethazine Brand names, Promethazine Analogs

Promethazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethazine Chemical_Formula


Promethazine RX_link

Promethazine fda sheet

Promethazine FDA

Promethazine msds (material safety sheet)

Promethazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethazine Molecular Weight

284.42 g/mol

Promethazine Melting Point


Promethazine H2O Solubility

Freely soluble

Promethazine State


Promethazine LogP


Promethazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promethazine Patient Information

Promethazine Organisms Affected

Humans and other mammals