Guaifenesin
Brand names,
Guaifenesin
Analogs
Guaifenesin
Brand Names Mixture
Guaifenesin
Chemical_Formula
C10H14O4
Guaifenesin
RX_link
http://www.rxlist.com/cgi/generic2/guaifen.htm
Guaifenesin
fda sheet
Guaifenesin
msds (material safety sheet)
Guaifenesin
Synthesis Reference
No information avaliable
Guaifenesin
Molecular Weight
198.216 g/mol
Guaifenesin
Melting Point
78.5 oC
Guaifenesin
H2O Solubility
50 mg/mL
Guaifenesin
State
Solid
Guaifenesin
LogP
0.95
Guaifenesin
Dosage Forms
Liquid; Powder for solution; Syrup; Tablet
Guaifenesin
Indication
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Guaifenesin
Pharmacology
Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
Guaifenesin
Absorption
Rapidly absorbed from the GI tract
Guaifenesin
side effects and Toxicity
LD50 1510 mg/kg (rat, oral)
Guaifenesin
Patient Information
No information avaliable
Guaifenesin
Organisms Affected
Humans and other mammals