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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C10H14O4
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RX_link
http://www.rxlist.com/cgi/generic2/guaifen.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
198.216 g/mol
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Melting Point
78.5 oC
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H2O Solubility
50 mg/mL
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State
Solid
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LogP
0.95
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Dosage Forms
Liquid; Powder for solution; Syrup; Tablet
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Indication
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
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Pharmacology
Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
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Absorption
Rapidly absorbed from the GI tract
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side effects and Toxicity
LD50 1510 mg/kg (rat, oral)
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals