Otofuran
Brand names,
Otofuran
Analogs
Otofuran
Brand Names Mixture
Otofuran
Chemical_Formula
C6H6N4O4
Otofuran
RX_link
No information avaliable
Otofuran
fda sheet
Otofuran
msds (material safety sheet)
Otofuran
Synthesis Reference
No information avaliable
Otofuran
Molecular Weight
198.136 g/mol
Otofuran
Melting Point
238 oC
Otofuran
H2O Solubility
210 mg/L (Approximately 50%)
Otofuran
State
Solid
Otofuran
LogP
0.517
Otofuran
Dosage Forms
Ointment
Otofuran
Indication
For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.
Otofuran
Pharmacology
Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.
Otofuran
Absorption
Well absorbed.
Otofuran
side effects and Toxicity
Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.
Otofuran
Patient Information
No information avaliable
Otofuran
Organisms Affected
Gram negative and gram positive bacteria