Nefco
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C6H6N4O4
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
198.136 g/mol
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Melting Point
238 oC
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H2O Solubility
210 mg/L (Approximately 50%)
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State
Solid
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LogP
0.517
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Dosage Forms
Ointment
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Indication
For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.
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Pharmacology
Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.
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Absorption
Well absorbed.
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side effects and Toxicity
Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.
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Patient Information
No information avaliable
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Organisms Affected
Gram negative and gram positive bacteria