Thiuram Disulfide, Tetraethyl- en es it fr

Thiuram Disulfide, Tetraethyl- Brand names, Thiuram Disulfide, Tetraethyl- Analogs

Thiuram Disulfide, Tetraethyl- Brand Names Mixture

  • No information avaliable

Thiuram Disulfide, Tetraethyl- Chemical_Formula

C10H20N2S4

Thiuram Disulfide, Tetraethyl- RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Thiuram Disulfide, Tetraethyl- fda sheet

Thiuram Disulfide, Tetraethyl- msds (material safety sheet)

Thiuram_Disulfide,_Tetraethyl- MSDS

Thiuram Disulfide, Tetraethyl- Synthesis Reference

No information avaliable

Thiuram Disulfide, Tetraethyl- Molecular Weight

296.543 g/mol

Thiuram Disulfide, Tetraethyl- Melting Point

71.5 oC

Thiuram Disulfide, Tetraethyl- H2O Solubility

4.09 mg/L

Thiuram Disulfide, Tetraethyl- State

Solid

Thiuram Disulfide, Tetraethyl- LogP

4.422

Thiuram Disulfide, Tetraethyl- Dosage Forms

Tablet

Thiuram Disulfide, Tetraethyl- Indication

For the treatment and management of chronic alcoholism

Thiuram Disulfide, Tetraethyl- Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Thiuram Disulfide, Tetraethyl- Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Thiuram Disulfide, Tetraethyl- side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Thiuram Disulfide, Tetraethyl- Patient Information

No information avaliable

Thiuram Disulfide, Tetraethyl- Organisms Affected

Humans and other mammals