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Nocbin Brand names, Nocbin Analogs

Nocbin Brand Names Mixture

  • No information avaliable

Nocbin Chemical_Formula


Nocbin RX_link

Nocbin fda sheet

Nocbin msds (material safety sheet)

Nocbin MSDS

Nocbin Synthesis Reference

No information avaliable

Nocbin Molecular Weight

296.543 g/mol

Nocbin Melting Point

71.5 oC

Nocbin H2O Solubility

4.09 mg/L

Nocbin State


Nocbin LogP


Nocbin Dosage Forms


Nocbin Indication

For the treatment and management of chronic alcoholism

Nocbin Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Nocbin Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Nocbin side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Nocbin Patient Information

No information avaliable

Nocbin Organisms Affected

Humans and other mammals