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Tetradine Brand names, Tetradine Analogs

Tetradine Brand Names Mixture

  • No information avaliable

Tetradine Chemical_Formula


Tetradine RX_link


Tetradine fda sheet

Tetradine msds (material safety sheet)

Tetradine MSDS

Tetradine Synthesis Reference

No information avaliable

Tetradine Molecular Weight

296.543 g/mol

Tetradine Melting Point

71.5 oC

Tetradine H2O Solubility

4.09 mg/L

Tetradine State


Tetradine LogP


Tetradine Dosage Forms


Tetradine Indication

For the treatment and management of chronic alcoholism

Tetradine Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Tetradine Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Tetradine side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Tetradine Patient Information

No information avaliable

Tetradine Organisms Affected

Humans and other mammals