Antiaethan
Brand names,
Antiaethan
Analogs
Antiaethan
Brand Names Mixture
Antiaethan
Chemical_Formula
C10H20N2S4
Antiaethan
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Antiaethan
fda sheet
Antiaethan
msds (material safety sheet)
Antiaethan
Synthesis Reference
No information avaliable
Antiaethan
Molecular Weight
296.543 g/mol
Antiaethan
Melting Point
71.5 oC
Antiaethan
H2O Solubility
4.09 mg/L
Antiaethan
State
Solid
Antiaethan
LogP
4.422
Antiaethan
Dosage Forms
Tablet
Antiaethan
Indication
For the treatment and management of chronic alcoholism
Antiaethan
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Antiaethan
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Antiaethan
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Antiaethan
Patient Information
No information avaliable
Antiaethan
Organisms Affected
Humans and other mammals