Antivitium

Antivitium Brand names, Antivitium Analogs

Antivitium Brand Names Mixture

No information avaliable

Antivitium Chemical_Formula

C₁₀H₂₀N₂S₄

Antivitium RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Antivitium fda sheet

Antivitium msds (material safety sheet)

Antivitium MSDS

Antivitium Synthesis Reference

No information avaliable

Antivitium Molecular Weight

296.543 g/mol

Antivitium Melting Point

71.5 ^oC

Antivitium H₂O Solubility

4.09 mg/L

Antivitium State

Solid

Antivitium LogP

4.422

Antivitium Dosage Forms

Tablet

Antivitium Indication

For the treatment and management of chronic alcoholism

Antivitium Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Antivitium Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Antivitium side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Antivitium Patient Information