Tetraethylthiuran Disulfide
Brand names,
Tetraethylthiuran Disulfide
Analogs
Tetraethylthiuran Disulfide
Brand Names Mixture
Tetraethylthiuran Disulfide
Chemical_Formula
C10H20N2S4
Tetraethylthiuran Disulfide
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Tetraethylthiuran Disulfide
fda sheet
Tetraethylthiuran Disulfide
msds (material safety sheet)
Tetraethylthiuran Disulfide
Synthesis Reference
No information avaliable
Tetraethylthiuran Disulfide
Molecular Weight
296.543 g/mol
Tetraethylthiuran Disulfide
Melting Point
71.5 oC
Tetraethylthiuran Disulfide
H2O Solubility
4.09 mg/L
Tetraethylthiuran Disulfide
State
Solid
Tetraethylthiuran Disulfide
LogP
4.422
Tetraethylthiuran Disulfide
Dosage Forms
Tablet
Tetraethylthiuran Disulfide
Indication
For the treatment and management of chronic alcoholism
Tetraethylthiuran Disulfide
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Tetraethylthiuran Disulfide
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Tetraethylthiuran Disulfide
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Tetraethylthiuran Disulfide
Patient Information
No information avaliable
Tetraethylthiuran Disulfide
Organisms Affected
Humans and other mammals