Ethyldithiourame en es it fr

Ethyldithiourame Brand names, Ethyldithiourame Analogs

Ethyldithiourame Brand Names Mixture

  • No information avaliable

Ethyldithiourame Chemical_Formula


Ethyldithiourame RX_link

Ethyldithiourame fda sheet

Ethyldithiourame msds (material safety sheet)

Ethyldithiourame MSDS

Ethyldithiourame Synthesis Reference

No information avaliable

Ethyldithiourame Molecular Weight

296.543 g/mol

Ethyldithiourame Melting Point

71.5 oC

Ethyldithiourame H2O Solubility

4.09 mg/L

Ethyldithiourame State


Ethyldithiourame LogP


Ethyldithiourame Dosage Forms


Ethyldithiourame Indication

For the treatment and management of chronic alcoholism

Ethyldithiourame Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Ethyldithiourame Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Ethyldithiourame side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Ethyldithiourame Patient Information

No information avaliable

Ethyldithiourame Organisms Affected

Humans and other mammals