Dupon 4472

Dupon 4472 Brand names, Dupon 4472 Analogs

Dupon 4472 Brand Names Mixture

No information avaliable

Dupon 4472 Chemical_Formula

C₁₀H₂₀N₂S₄

Dupon 4472 RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Dupon 4472 fda sheet

Dupon 4472 msds (material safety sheet)

Dupon_4472 MSDS

Dupon 4472 Synthesis Reference

No information avaliable

Dupon 4472 Molecular Weight

296.543 g/mol

Dupon 4472 Melting Point

71.5 ^oC

Dupon 4472 H₂O Solubility

4.09 mg/L

Dupon 4472 State

Solid

Dupon 4472 LogP

4.422

Dupon 4472 Dosage Forms

Tablet

Dupon 4472 Indication

For the treatment and management of chronic alcoholism

Dupon 4472 Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Dupon 4472 Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Dupon 4472 side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Dupon 4472 Patient Information