Tetraethylthioperoxydicarbonic Diamide

Tetraethylthioperoxydicarbonic Diamide Brand names, Tetraethylthioperoxydicarbonic Diamide Analogs

Tetraethylthioperoxydicarbonic Diamide Brand Names Mixture

No information avaliable

Tetraethylthioperoxydicarbonic Diamide Chemical_Formula

C₁₀H₂₀N₂S₄

Tetraethylthioperoxydicarbonic Diamide RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Tetraethylthioperoxydicarbonic Diamide fda sheet

Tetraethylthioperoxydicarbonic Diamide msds (material safety sheet)

Tetraethylthioperoxydicarbonic_Diamide MSDS

Tetraethylthioperoxydicarbonic Diamide Synthesis Reference

No information avaliable

Tetraethylthioperoxydicarbonic Diamide Molecular Weight

296.543 g/mol

Tetraethylthioperoxydicarbonic Diamide Melting Point

71.5 ^oC

Tetraethylthioperoxydicarbonic Diamide H₂O Solubility

4.09 mg/L

Tetraethylthioperoxydicarbonic Diamide State

Solid

Tetraethylthioperoxydicarbonic Diamide LogP

4.422

Tetraethylthioperoxydicarbonic Diamide Dosage Forms

Tablet

Tetraethylthioperoxydicarbonic Diamide Indication

For the treatment and management of chronic alcoholism

Tetraethylthioperoxydicarbonic Diamide Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Tetraethylthioperoxydicarbonic Diamide Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Tetraethylthioperoxydicarbonic Diamide side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Tetraethylthioperoxydicarbonic Diamide Patient Information