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Tillram Brand names, Tillram Analogs

Tillram Brand Names Mixture

  • No information avaliable

Tillram Chemical_Formula


Tillram RX_link


Tillram fda sheet

Tillram msds (material safety sheet)

Tillram MSDS

Tillram Synthesis Reference

No information avaliable

Tillram Molecular Weight

296.543 g/mol

Tillram Melting Point

71.5 oC

Tillram H2O Solubility

4.09 mg/L

Tillram State


Tillram LogP


Tillram Dosage Forms


Tillram Indication

For the treatment and management of chronic alcoholism

Tillram Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Tillram Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Tillram side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Tillram Patient Information

No information avaliable

Tillram Organisms Affected

Humans and other mammals