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Alk-Aubs Brand names, Alk-Aubs Analogs

Alk-Aubs Brand Names Mixture

  • No information avaliable

Alk-Aubs Chemical_Formula


Alk-Aubs RX_link

Alk-Aubs fda sheet

Alk-Aubs msds (material safety sheet)

Alk-Aubs MSDS

Alk-Aubs Synthesis Reference

No information avaliable

Alk-Aubs Molecular Weight

296.543 g/mol

Alk-Aubs Melting Point

71.5 oC

Alk-Aubs H2O Solubility

4.09 mg/L

Alk-Aubs State


Alk-Aubs LogP


Alk-Aubs Dosage Forms


Alk-Aubs Indication

For the treatment and management of chronic alcoholism

Alk-Aubs Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Alk-Aubs Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Alk-Aubs side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Alk-Aubs Patient Information

No information avaliable

Alk-Aubs Organisms Affected

Humans and other mammals