Dupont Fungicide 4472
Brand names,
Dupont Fungicide 4472
Analogs
Dupont Fungicide 4472
Brand Names Mixture
Dupont Fungicide 4472
Chemical_Formula
C10H20N2S4
Dupont Fungicide 4472
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Dupont Fungicide 4472
fda sheet
Dupont Fungicide 4472
msds (material safety sheet)
Dupont Fungicide 4472
Synthesis Reference
No information avaliable
Dupont Fungicide 4472
Molecular Weight
296.543 g/mol
Dupont Fungicide 4472
Melting Point
71.5 oC
Dupont Fungicide 4472
H2O Solubility
4.09 mg/L
Dupont Fungicide 4472
State
Solid
Dupont Fungicide 4472
LogP
4.422
Dupont Fungicide 4472
Dosage Forms
Tablet
Dupont Fungicide 4472
Indication
For the treatment and management of chronic alcoholism
Dupont Fungicide 4472
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Dupont Fungicide 4472
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Dupont Fungicide 4472
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Dupont Fungicide 4472
Patient Information
No information avaliable
Dupont Fungicide 4472
Organisms Affected
Humans and other mammals