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TATD Brand names, TATD Analogs

TATD Brand Names Mixture

  • No information avaliable

TATD Chemical_Formula

C10H20N2S4

TATD RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

TATD fda sheet

TATD msds (material safety sheet)

TATD MSDS

TATD Synthesis Reference

No information avaliable

TATD Molecular Weight

296.543 g/mol

TATD Melting Point

71.5 oC

TATD H2O Solubility

4.09 mg/L

TATD State

Solid

TATD LogP

4.422

TATD Dosage Forms

Tablet

TATD Indication

For the treatment and management of chronic alcoholism

TATD Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

TATD Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

TATD side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

TATD Patient Information

No information avaliable

TATD Organisms Affected

Humans and other mammals