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TETD Brand names, TETD Analogs

TETD Brand Names Mixture

  • No information avaliable

TETD Chemical_Formula


TETD RX_link


TETD fda sheet

TETD msds (material safety sheet)


TETD Synthesis Reference

No information avaliable

TETD Molecular Weight

296.543 g/mol

TETD Melting Point

71.5 oC

TETD H2O Solubility

4.09 mg/L

TETD State




TETD Dosage Forms


TETD Indication

For the treatment and management of chronic alcoholism

TETD Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

TETD Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

TETD side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

TETD Patient Information

No information avaliable

TETD Organisms Affected

Humans and other mammals