Contrapot en es it fr

Contrapot Brand names, Contrapot Analogs

Contrapot Brand Names Mixture

  • No information avaliable

Contrapot Chemical_Formula


Contrapot RX_link

Contrapot fda sheet

Contrapot msds (material safety sheet)

Contrapot MSDS

Contrapot Synthesis Reference

No information avaliable

Contrapot Molecular Weight

296.543 g/mol

Contrapot Melting Point

71.5 oC

Contrapot H2O Solubility

4.09 mg/L

Contrapot State


Contrapot LogP


Contrapot Dosage Forms


Contrapot Indication

For the treatment and management of chronic alcoholism

Contrapot Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Contrapot Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Contrapot side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Contrapot Patient Information

No information avaliable

Contrapot Organisms Affected

Humans and other mammals