Usaf B-33

Usaf B-33 Brand names, Usaf B-33 Analogs

Usaf B-33 Brand Names Mixture

No information avaliable

Usaf B-33 Chemical_Formula

C₁₀H₂₀N₂S₄

Usaf B-33 RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Usaf B-33 fda sheet

Usaf B-33 msds (material safety sheet)

Usaf_B-33 MSDS

Usaf B-33 Synthesis Reference

No information avaliable

Usaf B-33 Molecular Weight

296.543 g/mol

Usaf B-33 Melting Point

71.5 ^oC

Usaf B-33 H₂O Solubility

4.09 mg/L

Usaf B-33 State

Solid

Usaf B-33 LogP

4.422

Usaf B-33 Dosage Forms

Tablet

Usaf B-33 Indication

For the treatment and management of chronic alcoholism

Usaf B-33 Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Usaf B-33 Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Usaf B-33 side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Usaf B-33 Patient Information