Ethyl Tuads Rodform
Brand names,
Ethyl Tuads Rodform
Analogs
Ethyl Tuads Rodform
Brand Names Mixture
Ethyl Tuads Rodform
Chemical_Formula
C10H20N2S4
Ethyl Tuads Rodform
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Ethyl Tuads Rodform
fda sheet
Ethyl Tuads Rodform
msds (material safety sheet)
Ethyl Tuads Rodform
Synthesis Reference
No information avaliable
Ethyl Tuads Rodform
Molecular Weight
296.543 g/mol
Ethyl Tuads Rodform
Melting Point
71.5 oC
Ethyl Tuads Rodform
H2O Solubility
4.09 mg/L
Ethyl Tuads Rodform
State
Solid
Ethyl Tuads Rodform
LogP
4.422
Ethyl Tuads Rodform
Dosage Forms
Tablet
Ethyl Tuads Rodform
Indication
For the treatment and management of chronic alcoholism
Ethyl Tuads Rodform
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Ethyl Tuads Rodform
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Ethyl Tuads Rodform
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Ethyl Tuads Rodform
Patient Information
No information avaliable
Ethyl Tuads Rodform
Organisms Affected
Humans and other mammals