Hocakrotenalnci-C02959
Brand names,
Hocakrotenalnci-C02959
Analogs
Hocakrotenalnci-C02959
Brand Names Mixture
Hocakrotenalnci-C02959
Chemical_Formula
C10H20N2S4
Hocakrotenalnci-C02959
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Hocakrotenalnci-C02959
fda sheet
Hocakrotenalnci-C02959
msds (material safety sheet)
Hocakrotenalnci-C02959
Synthesis Reference
No information avaliable
Hocakrotenalnci-C02959
Molecular Weight
296.543 g/mol
Hocakrotenalnci-C02959
Melting Point
71.5 oC
Hocakrotenalnci-C02959
H2O Solubility
4.09 mg/L
Hocakrotenalnci-C02959
State
Solid
Hocakrotenalnci-C02959
LogP
4.422
Hocakrotenalnci-C02959
Dosage Forms
Tablet
Hocakrotenalnci-C02959
Indication
For the treatment and management of chronic alcoholism
Hocakrotenalnci-C02959
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Hocakrotenalnci-C02959
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Hocakrotenalnci-C02959
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Hocakrotenalnci-C02959
Patient Information
No information avaliable
Hocakrotenalnci-C02959
Organisms Affected
Humans and other mammals