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Tetidis Brand names, Tetidis Analogs

Tetidis Brand Names Mixture

  • No information avaliable

Tetidis Chemical_Formula

C10H20N2S4

Tetidis RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Tetidis fda sheet

Tetidis msds (material safety sheet)

Tetidis MSDS

Tetidis Synthesis Reference

No information avaliable

Tetidis Molecular Weight

296.543 g/mol

Tetidis Melting Point

71.5 oC

Tetidis H2O Solubility

4.09 mg/L

Tetidis State

Solid

Tetidis LogP

4.422

Tetidis Dosage Forms

Tablet

Tetidis Indication

For the treatment and management of chronic alcoholism

Tetidis Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Tetidis Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Tetidis side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Tetidis Patient Information

No information avaliable

Tetidis Organisms Affected

Humans and other mammals