Tetraethylthiram Disulfide
Brand names,
Tetraethylthiram Disulfide
Analogs
Tetraethylthiram Disulfide
Brand Names Mixture
Tetraethylthiram Disulfide
Chemical_Formula
C10H20N2S4
Tetraethylthiram Disulfide
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Tetraethylthiram Disulfide
fda sheet
Tetraethylthiram Disulfide
msds (material safety sheet)
Tetraethylthiram Disulfide
Synthesis Reference
No information avaliable
Tetraethylthiram Disulfide
Molecular Weight
296.543 g/mol
Tetraethylthiram Disulfide
Melting Point
71.5 oC
Tetraethylthiram Disulfide
H2O Solubility
4.09 mg/L
Tetraethylthiram Disulfide
State
Solid
Tetraethylthiram Disulfide
LogP
4.422
Tetraethylthiram Disulfide
Dosage Forms
Tablet
Tetraethylthiram Disulfide
Indication
For the treatment and management of chronic alcoholism
Tetraethylthiram Disulfide
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Tetraethylthiram Disulfide
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Tetraethylthiram Disulfide
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Tetraethylthiram Disulfide
Patient Information
No information avaliable
Tetraethylthiram Disulfide
Organisms Affected
Humans and other mammals