Ro-Sulfiram en es it fr

Ro-Sulfiram Brand names, Ro-Sulfiram Analogs

Ro-Sulfiram Brand Names Mixture

  • No information avaliable

Ro-Sulfiram Chemical_Formula


Ro-Sulfiram RX_link

Ro-Sulfiram fda sheet

Ro-Sulfiram msds (material safety sheet)

Ro-Sulfiram MSDS

Ro-Sulfiram Synthesis Reference

No information avaliable

Ro-Sulfiram Molecular Weight

296.543 g/mol

Ro-Sulfiram Melting Point

71.5 oC

Ro-Sulfiram H2O Solubility

4.09 mg/L

Ro-Sulfiram State


Ro-Sulfiram LogP


Ro-Sulfiram Dosage Forms


Ro-Sulfiram Indication

For the treatment and management of chronic alcoholism

Ro-Sulfiram Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Ro-Sulfiram Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Ro-Sulfiram side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Ro-Sulfiram Patient Information

No information avaliable

Ro-Sulfiram Organisms Affected

Humans and other mammals