Exhoran
Brand names,
Exhoran
Analogs
Exhoran
Brand Names Mixture
Exhoran
Chemical_Formula
C10H20N2S4
Exhoran
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Exhoran
fda sheet
Exhoran
msds (material safety sheet)
Exhoran
Synthesis Reference
No information avaliable
Exhoran
Molecular Weight
296.543 g/mol
Exhoran
Melting Point
71.5 oC
Exhoran
H2O Solubility
4.09 mg/L
Exhoran
State
Solid
Exhoran
LogP
4.422
Exhoran
Dosage Forms
Tablet
Exhoran
Indication
For the treatment and management of chronic alcoholism
Exhoran
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Exhoran
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Exhoran
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Exhoran
Patient Information
No information avaliable
Exhoran
Organisms Affected
Humans and other mammals