Cronetal

Cronetal Brand names, Cronetal Analogs

Cronetal Brand Names Mixture

No information avaliable

Cronetal Chemical_Formula

C₁₀H₂₀N₂S₄

Cronetal RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Cronetal fda sheet

Cronetal msds (material safety sheet)

Cronetal MSDS

Cronetal Synthesis Reference

No information avaliable

Cronetal Molecular Weight

296.543 g/mol

Cronetal Melting Point

71.5 ^oC

Cronetal H₂O Solubility

4.09 mg/L

Cronetal State

Solid

Cronetal LogP

4.422

Cronetal Dosage Forms

Tablet

Cronetal Indication

For the treatment and management of chronic alcoholism

Cronetal Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Cronetal Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Cronetal side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Cronetal Patient Information