Tetraethylthiuram en es it fr

Tetraethylthiuram Brand names, Tetraethylthiuram Analogs

Tetraethylthiuram Brand Names Mixture

  • No information avaliable

Tetraethylthiuram Chemical_Formula


Tetraethylthiuram RX_link


Tetraethylthiuram fda sheet

Tetraethylthiuram msds (material safety sheet)

Tetraethylthiuram MSDS

Tetraethylthiuram Synthesis Reference

No information avaliable

Tetraethylthiuram Molecular Weight

296.543 g/mol

Tetraethylthiuram Melting Point

71.5 oC

Tetraethylthiuram H2O Solubility

4.09 mg/L

Tetraethylthiuram State


Tetraethylthiuram LogP


Tetraethylthiuram Dosage Forms


Tetraethylthiuram Indication

For the treatment and management of chronic alcoholism

Tetraethylthiuram Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Tetraethylthiuram Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Tetraethylthiuram side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Tetraethylthiuram Patient Information

No information avaliable

Tetraethylthiuram Organisms Affected

Humans and other mammals