Antaethyl
Brand names,
Antaethyl
Analogs
Antaethyl
Brand Names Mixture
Antaethyl
Chemical_Formula
C10H20N2S4
Antaethyl
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Antaethyl
fda sheet
Antaethyl
msds (material safety sheet)
Antaethyl
Synthesis Reference
No information avaliable
Antaethyl
Molecular Weight
296.543 g/mol
Antaethyl
Melting Point
71.5 oC
Antaethyl
H2O Solubility
4.09 mg/L
Antaethyl
State
Solid
Antaethyl
LogP
4.422
Antaethyl
Dosage Forms
Tablet
Antaethyl
Indication
For the treatment and management of chronic alcoholism
Antaethyl
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Antaethyl
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Antaethyl
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Antaethyl
Patient Information
No information avaliable
Antaethyl
Organisms Affected
Humans and other mammals