Ekagom Teds

Ekagom Teds Brand names, Ekagom Teds Analogs

Ekagom Teds Brand Names Mixture

No information avaliable

Ekagom Teds Chemical_Formula

C₁₀H₂₀N₂S₄

Ekagom Teds RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Ekagom Teds fda sheet

Ekagom Teds msds (material safety sheet)

Ekagom_Teds MSDS

Ekagom Teds Synthesis Reference

No information avaliable

Ekagom Teds Molecular Weight

296.543 g/mol

Ekagom Teds Melting Point

71.5 ^oC

Ekagom Teds H₂O Solubility

4.09 mg/L

Ekagom Teds State

Solid

Ekagom Teds LogP

4.422

Ekagom Teds Dosage Forms

Tablet

Ekagom Teds Indication

For the treatment and management of chronic alcoholism

Ekagom Teds Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Ekagom Teds Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Ekagom Teds side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Ekagom Teds Patient Information