Ekagom Dtet

Ekagom Dtet Brand names, Ekagom Dtet Analogs

Ekagom Dtet Brand Names Mixture

No information avaliable

Ekagom Dtet Chemical_Formula

C₁₀H₂₀N₂S₄

Ekagom Dtet RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Ekagom Dtet fda sheet

Ekagom Dtet msds (material safety sheet)

Ekagom_Dtet MSDS

Ekagom Dtet Synthesis Reference

No information avaliable

Ekagom Dtet Molecular Weight

296.543 g/mol

Ekagom Dtet Melting Point

71.5 ^oC

Ekagom Dtet H₂O Solubility

4.09 mg/L

Ekagom Dtet State

Solid

Ekagom Dtet LogP

4.422

Ekagom Dtet Dosage Forms

Tablet

Ekagom Dtet Indication

For the treatment and management of chronic alcoholism

Ekagom Dtet Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Ekagom Dtet Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Ekagom Dtet side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Ekagom Dtet Patient Information