Tetraethylthiram Disulphide
Brand names,
Tetraethylthiram Disulphide
Analogs
Tetraethylthiram Disulphide
Brand Names Mixture
Tetraethylthiram Disulphide
Chemical_Formula
C10H20N2S4
Tetraethylthiram Disulphide
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Tetraethylthiram Disulphide
fda sheet
Tetraethylthiram Disulphide
msds (material safety sheet)
Tetraethylthiram Disulphide
Synthesis Reference
No information avaliable
Tetraethylthiram Disulphide
Molecular Weight
296.543 g/mol
Tetraethylthiram Disulphide
Melting Point
71.5 oC
Tetraethylthiram Disulphide
H2O Solubility
4.09 mg/L
Tetraethylthiram Disulphide
State
Solid
Tetraethylthiram Disulphide
LogP
4.422
Tetraethylthiram Disulphide
Dosage Forms
Tablet
Tetraethylthiram Disulphide
Indication
For the treatment and management of chronic alcoholism
Tetraethylthiram Disulphide
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Tetraethylthiram Disulphide
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Tetraethylthiram Disulphide
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Tetraethylthiram Disulphide
Patient Information
No information avaliable
Tetraethylthiram Disulphide
Organisms Affected
Humans and other mammals