Refusal en es it fr

Refusal Brand names, Refusal Analogs

Refusal Brand Names Mixture

  • No information avaliable

Refusal Chemical_Formula


Refusal RX_link

Refusal fda sheet

Refusal msds (material safety sheet)

Refusal MSDS

Refusal Synthesis Reference

No information avaliable

Refusal Molecular Weight

296.543 g/mol

Refusal Melting Point

71.5 oC

Refusal H2O Solubility

4.09 mg/L

Refusal State


Refusal LogP


Refusal Dosage Forms


Refusal Indication

For the treatment and management of chronic alcoholism

Refusal Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Refusal Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Refusal side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Refusal Patient Information

No information avaliable

Refusal Organisms Affected

Humans and other mammals