Thiophos
Thiophos Brand names, Thiophos Analogs
Thiophos Brand Names Mixture
- No information avaliable
Thiophos Chemical_Formula
C5H15N2O3PS
Thiophos RX_link
http://www.rxlist.com/cgi/generic/amifostine.htm
Thiophos fda sheet
Thiophos msds (material safety sheet)
Thiophos Synthesis Reference
No information avaliable
Thiophos Molecular Weight
214.224 g/mol
Thiophos Melting Point
No information avaliable
Thiophos H2O Solubility
1000 mg/mL
Thiophos State
Solid
Thiophos LogP
-1.043
Thiophos Dosage Forms
Powder for solution
Thiophos Indication
For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
Thiophos Pharmacology
Amifostine is an organic thiophosphate cytoprotective agent indicated to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer or non-small cell lung cancer and also to reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer. Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite, believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.
Thiophos Absorption
No information avaliable
Thiophos side effects and Toxicity
Rat LD50: 826 mg/kg
Thiophos Patient Information
No information avaliable
Thiophos Organisms Affected
Humans and other mammals
