Nocceler Tet

Nocceler Tet Brand names, Nocceler Tet Analogs

Nocceler Tet Brand Names Mixture

No information avaliable

Nocceler Tet Chemical_Formula

C₁₀H₂₀N₂S₄

Nocceler Tet RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Nocceler Tet fda sheet

Nocceler Tet msds (material safety sheet)

Nocceler_Tet MSDS

Nocceler Tet Synthesis Reference

No information avaliable

Nocceler Tet Molecular Weight

296.543 g/mol

Nocceler Tet Melting Point

71.5 ^oC

Nocceler Tet H₂O Solubility

4.09 mg/L

Nocceler Tet State

Solid

Nocceler Tet LogP

4.422

Nocceler Tet Dosage Forms

Tablet

Nocceler Tet Indication

For the treatment and management of chronic alcoholism

Nocceler Tet Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Nocceler Tet Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Nocceler Tet side effects and Toxicity

LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Nocceler Tet Patient Information