Perkacit Tetd
Brand names,
Perkacit Tetd
Analogs
Perkacit Tetd
Brand Names Mixture
Perkacit Tetd
Chemical_Formula
C10H20N2S4
Perkacit Tetd
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Perkacit Tetd
fda sheet
Perkacit Tetd
msds (material safety sheet)
Perkacit Tetd
Synthesis Reference
No information avaliable
Perkacit Tetd
Molecular Weight
296.543 g/mol
Perkacit Tetd
Melting Point
71.5 oC
Perkacit Tetd
H2O Solubility
4.09 mg/L
Perkacit Tetd
State
Solid
Perkacit Tetd
LogP
4.422
Perkacit Tetd
Dosage Forms
Tablet
Perkacit Tetd
Indication
For the treatment and management of chronic alcoholism
Perkacit Tetd
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Perkacit Tetd
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Perkacit Tetd
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Perkacit Tetd
Patient Information
No information avaliable
Perkacit Tetd
Organisms Affected
Humans and other mammals