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Ethyldithiurame Brand names, Ethyldithiurame Analogs

Ethyldithiurame Brand Names Mixture

  • No information avaliable

Ethyldithiurame Chemical_Formula


Ethyldithiurame RX_link

Ethyldithiurame fda sheet

Ethyldithiurame msds (material safety sheet)

Ethyldithiurame MSDS

Ethyldithiurame Synthesis Reference

No information avaliable

Ethyldithiurame Molecular Weight

296.543 g/mol

Ethyldithiurame Melting Point

71.5 oC

Ethyldithiurame H2O Solubility

4.09 mg/L

Ethyldithiurame State


Ethyldithiurame LogP


Ethyldithiurame Dosage Forms


Ethyldithiurame Indication

For the treatment and management of chronic alcoholism

Ethyldithiurame Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Ethyldithiurame Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Ethyldithiurame side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Ethyldithiurame Patient Information

No information avaliable

Ethyldithiurame Organisms Affected

Humans and other mammals