Nocceler Tet-G
Brand names,
Nocceler Tet-G
Analogs
Nocceler Tet-G
Brand Names Mixture
Nocceler Tet-G
Chemical_Formula
C10H20N2S4
Nocceler Tet-G
RX_link
http://www.rxlist.com/cgi/generic/disulfiram.htm
Nocceler Tet-G
fda sheet
Nocceler Tet-G
msds (material safety sheet)
Nocceler Tet-G
Synthesis Reference
No information avaliable
Nocceler Tet-G
Molecular Weight
296.543 g/mol
Nocceler Tet-G
Melting Point
71.5 oC
Nocceler Tet-G
H2O Solubility
4.09 mg/L
Nocceler Tet-G
State
Solid
Nocceler Tet-G
LogP
4.422
Nocceler Tet-G
Dosage Forms
Tablet
Nocceler Tet-G
Indication
For the treatment and management of chronic alcoholism
Nocceler Tet-G
Pharmacology
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.
Nocceler Tet-G
Absorption
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Nocceler Tet-G
side effects and Toxicity
LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Nocceler Tet-G
Patient Information
No information avaliable
Nocceler Tet-G
Organisms Affected
Humans and other mammals