Gastron
Brand names,
Gastron
Analogs
Gastron
Brand Names Mixture
Gastron
Chemical_Formula
C14H22ClN3O2
Gastron
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Gastron
fda sheet
Gastron
msds (material safety sheet)
Gastron
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Gastron
Molecular Weight
299.796 g/mol
Gastron
Melting Point
147.25 oC
Gastron
H2O Solubility
200 mg/L
Gastron
State
Solid
Gastron
LogP
2.464
Gastron
Dosage Forms
Liquid; Syrup; Tablet
Gastron
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Gastron
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Gastron
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Gastron
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Gastron
Patient Information
Gastron
Organisms Affected
Humans and other mammals