Emperal
Brand names,
Emperal
Analogs
Emperal
Brand Names Mixture
Emperal
Chemical_Formula
C14H22ClN3O2
Emperal
RX_link
http://www.rxlist.com/cgi/generic2/metoclo.htm
Emperal
fda sheet
Emperal
msds (material safety sheet)
Emperal
Synthesis Reference
Thominet, U.S. Pat. 3,177,252 (1965)
Emperal
Molecular Weight
299.796 g/mol
Emperal
Melting Point
147.25 oC
Emperal
H2O Solubility
200 mg/L
Emperal
State
Solid
Emperal
LogP
2.464
Emperal
Dosage Forms
Liquid; Syrup; Tablet
Emperal
Indication
For the treatment of gastroesophageal reflux disease (GERD)
Emperal
Pharmacology
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future.
Emperal
Absorption
Rapidly and well absorbed (oral bioavailability 80±15.5%).
Emperal
side effects and Toxicity
Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
Emperal
Patient Information
Emperal
Organisms Affected
Humans and other mammals